CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro
DOI 10.1055/s-0031-1295953
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Autor:innenS Ziegler, R Bröring, G Gerken, JF Schlaak, J Timm
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: A hallmark of chronic infections with hepatotropic viruses such as HBV and HCV is the notoriously weak antiviral immune response by CD8 T cells. It is believed that the liver-specific environment can induce tolerance either by induction of dysfunctional CD8 T cells or by premature death of activated CD8 T cells. Recent reports from mouse models indicate that hepatocytes can act as antigen-presenting cell…
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Zitierempfehlung
S Ziegler, R Bröring, G Gerken, JF Schlaak, J Timm (2012) Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295953
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