CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells
DOI 10.1055/s-0031-1295954
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Nachweis in CareLit
Autor:innenDF Tschaharganeh, P Latzko, M Malz, F Dombrowski, M Evert, X Chen, T Brummelkamp, P Schirmacher, DF Calvisi, K Breuhahn
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The Hippo-pathway regulates organ size and homeostasis. Studies revealed that deletion of Hippo-pathway kinases (e.g. Mst1/2) or overexpression of the transcriptional co-activator YAP lead to liver cancer; however, the underlying molecular mechanism have not identified so far. We therefore aimed to define possible effector mechanisms mediating YAP-dependent oncogenic activity in liver cancer. Methods: SiRNA-kn…
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Zitierempfehlung
DF Tschaharganeh, P Latzko, M Malz, F Dombrowski, M Evert, X Chen, T Brummelkamp, P Schirmacher, DF Calvisi, K Breuhahn (2012) The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295954
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