CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin
DOI 10.1055/s-0031-1295959
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Autor:innenS Berchtold, J Lampe, T Weiland, S Schleicher, R Handgretinger, HG Kopp, J Reiser, F Stubenrauch, NP Malek, M Bitzer, UM Lauer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The oncolytic potential of measles vaccine virus (MeV) has been demonstrated in several tumor models but it has also been shown that primary and secondary resistances exist or may arise. To improve the oncolytic potential of MeV and to overcome resistances, a suicide gene (SCD) was inserted (MeV-SCD) which allows the systemic application of the prodrug 5-fluorocytosine (5-FC) which is locally converted…
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Zitierempfehlung
S Berchtold, J Lampe, T Weiland, S Schleicher, R Handgretinger, HG Kopp, J Reiser, F Stubenrauch, NP Malek, M Bitzer, UM Lauer (2012) Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295959
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