CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation
DOI 10.1055/s-0031-1295968
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Autor:innenJ Dzieran, J Fabian, H Weng, T Longerich, K Breuhahn, P Schirmacher, S Dooley, NM Meindl-Beinker
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hepatocellular carcinoma (HCC) is the third most deadliest cancer. As its phenotype is strongly heterogenic and with symptoms occurring very late, it is challenging to develop efficient therapies. TGF-ß is cytostatic towards hepatocytes in early disease, whereas it is discussed to convert to a tumor promoter during cancer progression. This potential switch in TGF-ß signaling and the heterogeneity of HCC results in a…
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Zitierempfehlung
J Dzieran, J Fabian, H Weng, T Longerich, K Breuhahn, P Schirmacher, S Dooley, NM Meindl-Beinker (2012) Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295968
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