CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load
DOI 10.1055/s-0031-1295982
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Autor:innenA Kloos, E Gürlevik, N Woller, N Strüver, M Manns, R Gerardy-Schahn, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Polysialic acid (pSia) is a cell surface antigen that plays an important role in neuronal development but is not expressed in most adult tissues. However, expression of pSia is reactivated during oncogenesis of several cancers of neuroendocrine origin including glioblastoma, rhabdomyosarcoma and small cell lung cancer (SCLC). pSia therefore represents an excellent tumor selective target for oncolytic adenovirus-base…
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Zitierempfehlung
A Kloos, E Gürlevik, N Woller, N Strüver, M Manns, R Gerardy-Schahn, S Kubicka, F Kühnel (2012) Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295982
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