CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications
DOI 10.1055/s-0031-1295990
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJU Marquardt, K Fischer, A Teufel, M Krupp, SS Thorgeirsson, PR Galle, S Strand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD-dependent deacetylases. It is involved in epigenetic regulation of many cellular processes such as DNA repair, fat metabolism, glucose homeostasis and aging by interacting with key molecules and signaling pathways such as NF-kB and HIF1A. Loss of SIRT6 results in uncontrolled glycolysis, triglyceride synthesis, and increased oxidative stress ultimately leadi…
Zitieren
Zitierempfehlung
JU Marquardt, K Fischer, A Teufel, M Krupp, SS Thorgeirsson, PR Galle, S Strand (2012) Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1295990
Mit CareLit weiterarbeiten