CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma
DOI 10.1055/s-0031-1296000
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Autor:innenR Pellegrino, O Neumann, P Schirmacher, T Longerich
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Compared to other cancers mutational inactivation of p53 is rare in hepatocellular carcinoma (HCC) in Western countries. The p53-interacting factors MDM4 and MDM2 are the main p53 regulators. 1q gains promote the upregulation of MDM4 in HCCs. However, these are not sufficient to explain the increased MDM4 activity observed in HCCs with balanced MDM4 gene locus. AKT1/2 are tyrosine kinases that promote cell survival.…
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Zitierempfehlung
R Pellegrino, O Neumann, P Schirmacher, T Longerich (2012) AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1296000
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