CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling
DOI 10.1055/s-0031-1296007
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Autor:innenJ Schrader, TT Gordon-Walker, M Fahl, AW Lohse, JP Iredale
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Hepatocellular carcinoma (HCC) develops almost exclusively on a background of chronic liver inflammation and cirrhosis. We have shown before, that hepatoma cells are able to sense and respond to the increased stiffness of the cirrhotic liver leading to increased cellular tension, stress fibre formation and proliferation. The FAK-Rho/ROCK-MLC2/Myosin pathway has been identified in other tissues to be a central regula…
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Zitierempfehlung
J Schrader, TT Gordon-Walker, M Fahl, AW Lohse, JP Iredale (2012) Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1296007
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