CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates
DOI 10.1055/s-0031-1296014
Bibliografische Angaben
Nachweis in CareLit
Autor:innenW Timo, K Klein, M Zimmermann, T speicher, S Venturelli, A Berger, H Bantel, A Königsrainer, M Schenk, TS Weiss, A Wendel, M Schwab, NP Malek, M Bitzer, UM Lauer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background & Aims: The current use of TNF in medical oncology is restricted since effective doses lead to profound hepatotoxicity. Interestingly, TNF-induced cytotoxicity is known to be a highly ATP-dependent process. In primary murine hepatocytes it was recognized that fructose transiently depletes ATP leading to a TNF resistance (Speicher et al., 2010). In light of the results obtained in the murine system, the go…
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Zitierempfehlung
W Timo, K Klein, M Zimmermann, T speicher, S Venturelli, A Berger, H Bantel, A Königsrainer, M Schenk, TS Weiss, A Wendel, M Schwab, NP Malek, M Bitzer, UM Lauer (2012) Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0031-1296014
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