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Biological role of the proapoptotic transcription factor CHOP in Idiopathic Pulmonary Fibrosis (IPF)

O Klymenko, C Ruppert, W Seeger, A Guenther, M Korfei · Pneumologie · Ausgabe 12/2011

DOI 10.1055/s-0031-1296114

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Autor:innenO Klymenko, C Ruppert, W Seeger, A Guenther, M Korfei
ZeitschriftPneumologie
Ausgabe12/2011
Jahrgang / SeitenNicht angegeben

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Introduction: Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive diffuse parenchymal lung disease (DPLD), with a median survival time of less than three years following diagnosis. The precise mechanism of IPF is still not fully understood but chronic injury of alveolar epithelial type-II cells (AECII) is increasingly accepted as key event. We have recently identified severe Endoplasmic Reticulum (ER) stre…

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O Klymenko, C Ruppert, W Seeger, A Guenther, M Korfei (2011) Biological role of the proapoptotic transcription factor CHOP in Idiopathic Pulmonary Fibrosis (IPF). Pneumologie (12). https://doi.org/10.1055/s-0031-1296114

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