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Relative role of hepatocyte growth factor in mediating epithelial cell-protective effects in lung fibrosis – a role of Bcl-xL induction

S Skwarna, I Henneke, W Seeger, A Guenther, C Ruppert · Pneumologie · Ausgabe 12/2011

DOI 10.1055/s-0031-1296150

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Autor:innenS Skwarna, I Henneke, W Seeger, A Guenther, C Ruppert
ZeitschriftPneumologie
Ausgabe12/2011
Jahrgang / SeitenNicht angegeben

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Einleitung: Hepatocyte growth factor (HGF) is a cytokine with pleiotropic functions during wound healing and repair. Anti-fibrotic effects have been shown in animal models of lung fibrosis and may be mediated via multiple direct and indirect mechanisms, including promoting endothelial and epithelial cell survival and proliferation and reduction of myofibroblast accumulation. In liver and kidney epithelial cells the…

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S Skwarna, I Henneke, W Seeger, A Guenther, C Ruppert (2011) Relative role of hepatocyte growth factor in mediating epithelial cell-protective effects in lung fibrosis – a role of Bcl-xL induction. Pneumologie (12). https://doi.org/10.1055/s-0031-1296150

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