CareLit · DOI-Nachweis · Pneumologie
Long-term Bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice
DOI 10.1055/s-0031-1296157
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Nachweis in CareLit
Autor:innenM Wegmann, L Lunding, Z Orinska, DM Wong, RA Manz, H Fehrenbach
ZeitschriftPneumologie
Ausgabe12/2011
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Since allergen-specific immuno-globulin E (IgE) enables mast cells and eosinophils to react on allergen-contact it plays a critical role in the formation of allergic inflammation and has been identified as a target for asthma therapy. By inhibiting the proteasome complex Bortezomib efficiently depletes Ig-secreting plasma cells and, thus, reduces Ig-serum titers. The present study evaluates the therape…
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Zitierempfehlung
M Wegmann, L Lunding, Z Orinska, DM Wong, RA Manz, H Fehrenbach (2011) Long-term Bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice. Pneumologie (12). https://doi.org/10.1055/s-0031-1296157
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