Alternative tumor suppressor mechanisms in lung carcinomas – modulation of senescence by growth factor-induced signaling

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Oncogene- induced senescence (irreversible cell cycle arrest) is recognized as an important tumor-suppressive mechanism, bypassing of which may contribute to malignant transformation of the cells. On the other hand, senescence induction, in addition to apoptosis stimulation and proliferation suppression, is responsible for the cytostatic activity of many commonly used anticancer drugs. Therefore, senescence escape m…

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