CareLit · DOI-Nachweis · Klinische Pädiatrie
Formation of atypical, hyperproliferating eosinophilic precursors by overexpression of GATA1s
DOI 10.1055/s-0032-1310470
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Maroz, C Hennig, B Van Handel, H Mikkola, D Reinhardt, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Transcription factor GATA1 is essential for the development of megakaryocytes, erythrocytes and eosinophils. GATA1-mutations (GATA1s) are associated with Down syndrome (DS) transient leukemia (TL). Here, we report a series of DS-TL patients with eosinophilia that carry the same GATA1s-mutation in the sorted eosinophils as in the leukemic blasts. To explore the effect of GATA1s on myeloid differentiation in the human…
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Zitierempfehlung
A Maroz, C Hennig, B Van Handel, H Mikkola, D Reinhardt, JH Klusmann (2012) Formation of atypical, hyperproliferating eosinophilic precursors by overexpression of GATA1s. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310470
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