CareLit · DOI-Nachweis · Klinische Pädiatrie
Characterization of oncogenes on chromosome 21 identified by shRNA-based viability screening
DOI 10.1055/s-0032-1310479
Bibliografische Angaben
Nachweis in CareLit
Autor:innenL Stachorski, VR Thangapandi, D Reinhardt, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Children with trisomy 21 (Down syndrome, DS) are predisposed to develop acute megakaryoblastic leukemia (DS-AMKL). Hypothesizing that the presence of an extra copy of human chromosome 21 (hsa21) is one basal requirement for the onset of DS-AMKL, we previously conducted a shRNA-based viability screening to identify those yet unknown oncogenic candidates. Methods: We analyzed how candidate oncogenes from…
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Zitierempfehlung
L Stachorski, VR Thangapandi, D Reinhardt, JH Klusmann (2012) Characterization of oncogenes on chromosome 21 identified by shRNA-based viability screening. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310479
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