CareLit · DOI-Nachweis · Klinische Pädiatrie
Preclinical evaluation of a novel treatment strategy to treat high risk ALL
DOI 10.1055/s-0032-1310481
Bibliografische Angaben
Nachweis in CareLit
Autor:innenMN Hasan, M Queudeville, SM Eckhoff, M Hermann, S Miller, L Trentin, KM Debatin, LH Meyer
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We recently showed that rapid engraftment of patient ALL in NOD/SCID mice is indicative for poor patient survival. Moreover, gene expression analysis identified differenzial expression of molecules regulating the mTOR pathway. We now functionally address mTOR activation assessing P-S6 levels in xenograft ALL and evaluate mTOR inhibition as novel treatment strategy ex vivo and in vivo. Increased P-S6 levels were dete…
Zitieren
Zitierempfehlung
MN Hasan, M Queudeville, SM Eckhoff, M Hermann, S Miller, L Trentin, KM Debatin, LH Meyer (2012) Preclinical evaluation of a novel treatment strategy to treat high risk ALL. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310481
Mit CareLit weiterarbeiten