CareLit · DOI-Nachweis · Klinische Pädiatrie
Depletion of RUNX1/ETO in t(8:21) AML cells leads to genome-wide changes in transcription factor binding
DOI 10.1055/s-0032-1310482
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Martinez, A Ptasinska, C Bonifer, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The t(8:21) translocation is present in approximately 15% of all acute myeloid leukemia (AML) cases. This fusion protein is a leukaemia-initiating transcription factor that interferes with RUNX1 function, resulting in a block in differentiation and in the development of AML. However the molecular details of the mechanism of deregulation are still obscure. It is important to identify RUNX1/ETO target sites at the gen…
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Zitierempfehlung
N Martinez, A Ptasinska, C Bonifer, O Heidenreich (2012) Depletion of RUNX1/ETO in t(8:21) AML cells leads to genome-wide changes in transcription factor binding. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310482
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