CareLit · DOI-Nachweis · Klinische Pädiatrie
The role of PAX5 fusion genes in the pathogenesis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
DOI 10.1055/s-0032-1310484
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Anderl, K Fortschegger, D Dagmar, S Strehl
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
PAX5 is an important transcription factor which controls B-lymphocyte development and is a frequent target of somatic mutations in BCP-ALL. In 2–3% of the cases genetic rearrangements lead to the expression of chimeric fusion proteins which are thought to act as aberrant transcription factors that antagonize normal PAX5 function. The aim of our study is to elucidate potential functional commonalities and differences…
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Zitierempfehlung
S Anderl, K Fortschegger, D Dagmar, S Strehl (2012) The role of PAX5 fusion genes in the pathogenesis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310484
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