CareLit · DOI-Nachweis · Klinische Pädiatrie
Timely controlled T cell receptor expression against a leukemia-associated antigen for the co-transplantation of MHC-mismatched T-cell precursors into hematopoietic stem cell (HCT) recipients
DOI 10.1055/s-0032-1310489
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Nachweis in CareLit
Autor:innenS Hoseini, M Hapke, J Herbst, N Heinz, B Schiedlmeyer, A Krüger, M Sauer
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Adoptive transfer (AT) of TCR-gene modified T cells has been associated with a couple of draw-backs. 1. Rigorous in vitro stimulation required for TCR-gene transduction can profoundly impact in vivo function after AT, 2. TCR-chain mispairing can cause potentially life threatening autoreactivity, and 3. HLA-matched T cell donors are required. Here we present a system designed to transduce stem cells with an anti-leuk…
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Zitierempfehlung
S Hoseini, M Hapke, J Herbst, N Heinz, B Schiedlmeyer, A Krüger, M Sauer (2012) Timely controlled T cell receptor expression against a leukemia-associated antigen for the co-transplantation of MHC-mismatched T-cell precursors into hematopoietic stem cell (HCT) recipients. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310489
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