CareLit · DOI-Nachweis · Klinische Pädiatrie
RITA – p53 activation in medulloblastoma as a new approach for treatment?
DOI 10.1055/s-0032-1310490
Bibliografische Angaben
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Autor:innenA Gottlieb, A Künkele, A Schramm, A Eggert, JH Schulte
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Current therapy of medulloblastoma (MB), the most common malignant brain tumor of childhood, achieves 40–70% survival. Chemotherapy resistence development contributes to treatment failure, where p53 pathway dysfunction plays a key role. Interaction of MDM2 with p53 leads to its degradation, and reactivating p53 functionality using small-molecule inhibitors, such as RITA, to disrupt p53-MDM2 binding may have therapeu…
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Zitierempfehlung
A Gottlieb, A Künkele, A Schramm, A Eggert, JH Schulte (2012) RITA – p53 activation in medulloblastoma as a new approach for treatment?. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310490
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