CareLit · DOI-Nachweis · Klinische Pädiatrie
LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling
DOI 10.1055/s-0032-1310498
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Lindner, J Molenaar, T Thor, A Sprüssel, HN Caron, R Versteeg, A Schramm, A Eggert, JH Schulte
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
LIN28b is overexpressed in many malignancies, including neuroblastoma (NB). LIN28b represses let-7 miRNAs which target MYC, RAS and MYCN. We here describe for the first time that LIN28b has the potential to initiate NBs. We established a genetically engineered mouse model overexpressing murine Lin28b in the neural crest and its derivates. The spontaneously arising tumors were analysed using IHC, western blot and RT-…
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Zitierempfehlung
S Lindner, J Molenaar, T Thor, A Sprüssel, HN Caron, R Versteeg, A Schramm, A Eggert, JH Schulte (2012) LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310498
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