CareLit · DOI-Nachweis · Klinische Pädiatrie
Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wildtype gliomas
DOI 10.1055/s-0032-1310500
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Müller, M Gessi, A Waha, LJ Isselstein, D Luxen, D Freihoff, J Freihoff, A Becker, M Simon, T Pietsch, A Waha
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
IDH1 mutations are associated with a CpG island methylator phenotype in glioblastomas. Cells harboring IDH1 mutations produce 2-hydroxyglutarate inhibiting TET enzymes involved in the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Glioma tissues and cell lines were investigated by RT-PCR, immunohistochemistry and pyrosequencing for the expression of TET enzymes, 5hmC content and IDH1 status r…
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Zitierempfehlung
T Müller, M Gessi, A Waha, LJ Isselstein, D Luxen, D Freihoff, J Freihoff, A Becker, M Simon, T Pietsch, A Waha (2012) Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wildtype gliomas. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310500
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