CareLit · DOI-Nachweis · Klinische Pädiatrie
GM-CSF is not able to induce granulopoiesis in CN patients due to absence of LEF-1 transcription factor
DOI 10.1055/s-0032-1310504
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Koch, K Welte, J Skokowa
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
G-CSF is successfully used to treat patients with severe congenital neutropenia (CN). However, daily treatment with high doses of G-CSF (up to 50µg/kg/d) are required to induce granulocyte numbers of above 1000/µl in CN patients. Intriguingly, GM-CSF failed even at high dosages (30µg/kg/day) to increase the neutrophil numbers, but led to a dramatic increase of eosinophils and monocytes in those patients. We aimed to…
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Zitierempfehlung
C Koch, K Welte, J Skokowa (2012) GM-CSF is not able to induce granulopoiesis in CN patients due to absence of LEF-1 transcription factor. Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310504
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