CareLit · DOI-Nachweis · Klinische Pädiatrie
NAMPT-dependent deacetylation of the hematopoietic-specific lyn-substrate 1 (HCLS1)
DOI 10.1055/s-0032-1310510
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Samareh, A Klaus, K Welte, J Skokowa
ZeitschriftKlinische Pädiatrie
Ausgabe04/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Recently, we demonstrated an essential role of the hematopoietic cell-specific Lyn substrate 1 (HCLS1 or HS1) protein in myeloid differentiation of human and mouse hematopoietic cells. HCLS1 is an interaction partner of HAX1, which is mutated in patients with severe congenital neutropenia (CN). In these patients HCLS1 expression and functions are severely downregulated, leading to “maturation arrest” of myelopoiesis…
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Zitierempfehlung
B Samareh, A Klaus, K Welte, J Skokowa (2012) NAMPT-dependent deacetylation of the hematopoietic-specific lyn-substrate 1 (HCLS1). Klinische Pädiatrie (04). https://doi.org/10.1055/s-0032-1310510
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