CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
NALP3 inflammasome activation is MYD88-, but not TLR4-dependent and involves both parenchymal and bone marrow derived cells in non-alcoholic steatohepatitis (NASH)
DOI 10.1055/s-0032-1312444
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Nachweis in CareLit
Autor:innenT Csak, A Villai, M Ganz, D Lippai, J Petrasek, B Nath, K Kodys, A Dolganiuc, E Kurt-Jones, G Szabo
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background and Aims: Endogenous danger signals from damaged hepatocytes in NASH might up-regulate and activate the inflammasome, that is a multiprotein complex that leads to IL-1ß secretion. We reported NALP3 inflammasome up-regulation activation in NASH. Here, we aimed to investigate the role of toll-like receptor 4 (TLR4) and the common TLR adaptor, MyD88 in the activation of NALP3 inflammasome. Furthermore, we ai…
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Zitierempfehlung
T Csak, A Villai, M Ganz, D Lippai, J Petrasek, B Nath, K Kodys, A Dolganiuc, E Kurt-Jones, G Szabo (2012) NALP3 inflammasome activation is MYD88-, but not TLR4-dependent and involves both parenchymal and bone marrow derived cells in non-alcoholic steatohepatitis (NASH). Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0032-1312444
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