CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
MSH3 deficiency initiates EMAST without protumorigenic transformation of human colon epithelial cells
DOI 10.1055/s-0032-1313846
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Autor:innenC Campregher, V Khare, G Schmid, AI Roig, B Kortüm, T Scharl, JW Shay, C Gerner, C Gasche
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is a genetic signature in certain cases of sporadic colorectal cancer and has been linked to MSH3-deficiency. It is currently unclear whether EMAST carries protumorigenic properties in humans, specifically as cancer development in MSH3-deficient mice is not enhanced. However, a mutator phenotype is different between species…
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Zitierempfehlung
C Campregher, V Khare, G Schmid, AI Roig, B Kortüm, T Scharl, JW Shay, C Gerner, C Gasche (2012) MSH3 deficiency initiates EMAST without protumorigenic transformation of human colon epithelial cells. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0032-1313846
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