CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Effects of Insulin Degrading Enzyme (IDE)-activity on the liver cancer cell transcriptome
DOI 10.1055/s-0032-1314515
Bibliografische Angaben
Nachweis in CareLit
Autor:innenO Pivovarova, I Ilkavets, S Zhuk, A Malashicheva, A Kostareva, S Dooley, AFH Pfeiffer, N Rudovich
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Type 2 diabetes mellitus (T2DM) characterized by hyperinsulinemia is an independent risk factor for development and progression of hepatocellular carcinoma. Insulin degrading enzyme (IDE) is a major enzyme responsible for insulin degradation. We and others demonstrated that metabolic modulation of IDE activity is more important for its overall action than alterations of its protein level. Inhibition of IDE act…
Zitieren
Zitierempfehlung
O Pivovarova, I Ilkavets, S Zhuk, A Malashicheva, A Kostareva, S Dooley, AFH Pfeiffer, N Rudovich (2012) Effects of Insulin Degrading Enzyme (IDE)-activity on the liver cancer cell transcriptome. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0032-1314515
Mit CareLit weiterarbeiten