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Region-specific regulation of mucus production in allergic asthma is dependent on IL-13R alpha 1 expression

C Vock, AÖ Yildirim, M Wegmann, H Fehrenbach · Pneumologie · Ausgabe 05/2012

DOI 10.1055/s-0032-1315472

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Autor:innenC Vock, AÖ Yildirim, M Wegmann, H Fehrenbach
ZeitschriftPneumologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Increased mucus production is a critical factor impairing lung function in patients suffering from bronchial asthma, the most common chronic inflammatory disease worldwide. In acute and chronic mouse models of allergic asthma metaplasia of mucus producing goblet cells (GC) was found in proximal but not in distal airways although secretion of interleukin (IL)-13, the main trigger of mucus production, was significantl…

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Zitierempfehlung

C Vock, AÖ Yildirim, M Wegmann, H Fehrenbach (2012) Region-specific regulation of mucus production in allergic asthma is dependent on IL-13R alpha 1 expression. Pneumologie (05). https://doi.org/10.1055/s-0032-1315472

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