CareLit · DOI-Nachweis · Pneumologie
DNA demethylation of the IFNγ locus attenuates experimentally induced asthma
DOI 10.1055/s-0032-1315480
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Kesper, S Brand, RO Pinkenburg, H Garn, PI Pfefferle, H Renz
ZeitschriftPneumologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Polarization of T cells towards a Th2 cell based immune reaction is one of the key events in the development of allergic asthma. During the polarization process the Th-1 cytokine IFNγ is silenced by epigenetic mechanisms like de novo DNA methylation while Th2 cytokines are up regulated. Method: In order to show that epigenetic regulation by DNA methylation is essential for Th1 versus Th2 cell polarizatio…
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Zitierempfehlung
D Kesper, S Brand, RO Pinkenburg, H Garn, PI Pfefferle, H Renz (2012) DNA demethylation of the IFNγ locus attenuates experimentally induced asthma. Pneumologie (05). https://doi.org/10.1055/s-0032-1315480
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