CareLit · DOI-Nachweis · Pneumologie
Biological role of the proapoptotic transcription factor C/EBP homologous protein (CHOP) in Idiopathic Pulmonary Fibrosis (IPF)
DOI 10.1055/s-0032-1315511
Bibliografische Angaben
Nachweis in CareLit
Autor:innenO Klymenko, C Ruppert, W Seeger, A Guenther, M Korfei
ZeitschriftPneumologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: We have recently identified severe and pro-apoptotic Endoplasmic Reticulum (ER) stress as major pathomechanism for alveolar epithelial cell (AEC) injury in Idiopathic Pulmonary Fibrosis (IPF). In line with this, the pro-apoptotic transcription factor CHOP, which functions as a crucial mediator of ER stress-induced apoptosis, was strongly induced in AECII from patients with IPF. We therefore aimed to fu…
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Zitierempfehlung
O Klymenko, C Ruppert, W Seeger, A Guenther, M Korfei (2012) Biological role of the proapoptotic transcription factor C/EBP homologous protein (CHOP) in Idiopathic Pulmonary Fibrosis (IPF). Pneumologie (05). https://doi.org/10.1055/s-0032-1315511
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