CareLit · DOI-Nachweis · Pneumologie
Aberrant expression and activity of histone deacetylases (HDACs) in lungs of patients with sporadic Idiopathic Pulmonary Fibrosis (IPF)
DOI 10.1055/s-0032-1315513
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Korfei, M Buchwald, W Klepetko, L Fink, W Seeger, O Kraemer, A Guenther
ZeitschriftPneumologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on histones, resulting in chromatin condensation and epigenetic repression of gene transcription. HDACs can also catalyze deacetylation of many non-histone proteins, such as the tumor suppressor p53, resulting in inhibition of its pro-apoptotic activity. HDACs thus greatly contribute to t…
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Zitierempfehlung
M Korfei, M Buchwald, W Klepetko, L Fink, W Seeger, O Kraemer, A Guenther (2012) Aberrant expression and activity of histone deacetylases (HDACs) in lungs of patients with sporadic Idiopathic Pulmonary Fibrosis (IPF). Pneumologie (05). https://doi.org/10.1055/s-0032-1315513
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