CareLit · DOI-Nachweis · Pneumologie
Constitutive knockdown of Napsin A does not result in a fibrotic lung phenotype in mice
DOI 10.1055/s-0032-1315515
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Autor:innenC Ruppert, M Korfei, I Henneke, W Seeger, A Günther
ZeitschriftPneumologie
Ausgabe05/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Napsin A (Napsa) is an aspartic protease present in alveolar epithelial type 2 cells (AECII) and essential for posttranslational protein processing of surfactant protein (SP)-B. Mutation in surfactant proteins have been linked to interstitial lung disease and we recently observed an abnormal accumulation of unprocessed SP-B and induction of an apoptotic endoplasmic reticulum (ER)-stress response in pat…
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Zitierempfehlung
C Ruppert, M Korfei, I Henneke, W Seeger, A Günther (2012) Constitutive knockdown of Napsin A does not result in a fibrotic lung phenotype in mice. Pneumologie (05). https://doi.org/10.1055/s-0032-1315515
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