CareLit · DOI-Nachweis · Klinische Pädiatrie
Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc- mediated downregulation of cFLIP
DOI 10.1055/s-0032-1320171
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Bangert, S Cristofanon, I Eckhardt, B Ahangarian Abhari, S Kolodziej, S Häcker, S Hari Krishna Vellanki, J Lausen, KM Debatin, S Fulda
ZeitschriftKlinische Pädiatrie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Glioblastoma is the most common primary brain tumor with a very poor prognosis, calling for novel treatment strategies. Here, we provide first evidence that histone deacetylase inhibitors (HDACI) prime glioblastoma cells for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis at least in part by c-myc-mediated downregulation of cellular FLICE-inhibitory protein (cFLIP). Pretreatment wi…
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Zitierempfehlung
A Bangert, S Cristofanon, I Eckhardt, B Ahangarian Abhari, S Kolodziej, S Häcker, S Hari Krishna Vellanki, J Lausen, KM Debatin, S Fulda (2012) Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc- mediated downregulation of cFLIP. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0032-1320171
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