CareLit · DOI-Nachweis · Klinische Pädiatrie
Investigation of BRAF fusion genes as a therapeutic target in pilocytic astrocytoma
DOI 10.1055/s-0032-1320173
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Cin, J Gronych, A Korshunov, DTW Jones, D Milford, T Milde, S Heiland, P Lichter, O Witt, SM Pfister
ZeitschriftKlinische Pädiatrie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Pilocytic astrocytomas (PAs) are the most common pediatric brain tumors. Despite the benign clinical behavior reported for PA, treatment of tumors in critical anatomic locations remains challenging, since tumors often respond to conventional chemo and radiationtherapy poorly. BRAF fusion genes, rendering the MAPK pathway constitutively active, were shown to comprise a hallmark genetic event in PA thus suggesting a p…
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Zitierempfehlung
H Cin, J Gronych, A Korshunov, DTW Jones, D Milford, T Milde, S Heiland, P Lichter, O Witt, SM Pfister (2012) Investigation of BRAF fusion genes as a therapeutic target in pilocytic astrocytoma. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0032-1320173
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