CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of p53 accumulation, EGFR gain and PDGFRα gain/amplification as adverse prognostic factors in pediatric high grade gliomas – evaluation of 48 cases of the German HIT-HGG trial
DOI 10.1055/s-0032-1320175
Bibliografische Angaben
Nachweis in CareLit
Autor:innenGH Gielen, A zur Mühlen, C Kramm, T Pietsch
ZeitschriftKlinische Pädiatrie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In adult high grade gliomas (HGG) genetic markers with prognostic/predictive impact including IDH1/2 mutation and MGMT promoter hypermethylation were identified. In contrast, the significance of these key markers remains still unclear in pediatric HGG which are considered to differ from adult HGG in their pathogenesis and biological behaviour. To investigate the frequency and prognostic impact of genetic alterations…
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Zitierempfehlung
GH Gielen, A zur Mühlen, C Kramm, T Pietsch (2012) Identification of p53 accumulation, EGFR gain and PDGFRα gain/amplification as adverse prognostic factors in pediatric high grade gliomas – evaluation of 48 cases of the German HIT-HGG trial. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0032-1320175
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