CareLit · DOI-Nachweis · Klinische Pädiatrie
DNA Damaging Drugs in the Treatment of Glioblastoma: HR, Apoptosis, Autophagy and Senescence
DOI 10.1055/s-0032-1320176
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Knizhnik, S Quiros, C Barckhausen, WP Roos, B Kaina
ZeitschriftKlinische Pädiatrie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Alkylating agents, notably temozolomide, are 1st line therapeutics for the treatment of glioma. These agents induce different DNA lesions. One of the DNA adducts is O6-methylguanine (O6MeG), which is a powerful cytotoxic lesion. The damage is repaired by the suicide enzyme alkyltransferase (MGMT), which is a very important defense mechanism and marker of alkylating drug resistance. We have studied in detail how apop…
Zitieren
Zitierempfehlung
A Knizhnik, S Quiros, C Barckhausen, WP Roos, B Kaina (2012) DNA Damaging Drugs in the Treatment of Glioblastoma: HR, Apoptosis, Autophagy and Senescence. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0032-1320176
Mit CareLit weiterarbeiten