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Combinatorial effects of Resveratrol, 5-aza-2'deoxycytidin, and irradiation on clonogenic survival and stem cell population in human Medulloblastoma cell lines

I Patties, RD Kortmann, A Glasow · Klinische Pädiatrie · Ausgabe 11/2012

DOI 10.1055/s-0032-1320180

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Autor:innenI Patties, RD Kortmann, A Glasow
ZeitschriftKlinische Pädiatrie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Recently, the efficiency of anticancer therapeutics is increasingly measured by their potential to eliminate a subpopulation of tumor cells, the so called tumorigenic stem cells (TSC). Also in medulloblastoma (MB), the most malignant embryonal brain tumor, such TSC were identified by expression of CD133 or CD15. In previous studies we could show a radioadditive effect of the demethylating agent 5-aza-2'deoxycytidin…

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I Patties, RD Kortmann, A Glasow (2012) Combinatorial effects of Resveratrol, 5-aza-2'deoxycytidin, and irradiation on clonogenic survival and stem cell population in human Medulloblastoma cell lines. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0032-1320180

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