CareLit · DOI-Nachweis · Klinische Pädiatrie
Actinomycin-D treatment of high-risk ependymomas re-establishes the apoptotic function of p53
DOI 10.1055/s-0032-1320183
Bibliografische Angaben
Nachweis in CareLit
Autor:innenTD Tzaridis, H Witt, T Milde, S Bender, E Pfaff, DTW Jones, AE Kulozik, P Lichter, A Korshunov, O Witt, SM Pfister
ZeitschriftKlinische Pädiatrie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aim of study: Ependymomas are brain tumours morphologically resembling the lining epithelium of the ventricular system of the CNS and account for 12% of all pediatric intracranial malignancies. Despite the absence of TP53 mutations, immunohistochemical accumulation of non-functional p53 is frequently observed in ependymomas and correlates with poor clinical outcome. Homozygous CDKN2A deletion is another common aberr…
Zitieren
Zitierempfehlung
TD Tzaridis, H Witt, T Milde, S Bender, E Pfaff, DTW Jones, AE Kulozik, P Lichter, A Korshunov, O Witt, SM Pfister (2012) Actinomycin-D treatment of high-risk ependymomas re-establishes the apoptotic function of p53. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0032-1320183
Mit CareLit weiterarbeiten