CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatic, MyD88-dependent toll-like receptors are activated by in vivo application of LNP01-formulated siRNAs
DOI 10.1055/s-0032-1323937
Bibliografische Angaben
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Autor:innenCI Real, R Broering, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: siRNAs are being developed for the therapeutic use in liver cancer, viral hepatitis, metabolic disorders and others. We have previously shown that chemical modifications of siRNAs may suppress immunologically mediated off-target effects in isolated liver cells in vitro. Here, we assessed efficacy and the Toll-like receptor dependent immune-stimulatory effects of differently modified siRNAs in vivo. Met…
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Zitierempfehlung
CI Real, R Broering, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, G Gerken, JF Schlaak (2012) Hepatic, MyD88-dependent toll-like receptors are activated by in vivo application of LNP01-formulated siRNAs. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1323937
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