CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
In vivo knockdown, mediated by LNP01-formulated siRNAs, of HCV pro-viral factor ISG15 increased responsiveness to Interferon
DOI 10.1055/s-0032-1323948
Bibliografische Angaben
Nachweis in CareLit
Autor:innenCI Real, R Broering, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Non-response of HCV patients to combination therapy has previously been associated with a strong up-regulation of the interferon stimulated gene 15 (ISG15). ISG15 has been identified as pro-viral host factor promoting HCV replication. Therefore, hepatocyte-specific suppression of ISG15 expression may be a promising approach to overcome non-response to standard combination treatment of HCV patients and…
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Zitierempfehlung
CI Real, R Broering, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, G Gerken, JF Schlaak (2012) In vivo knockdown, mediated by LNP01-formulated siRNAs, of HCV pro-viral factor ISG15 increased responsiveness to Interferon. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1323948
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