CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
In vivo delivery of siRNA to key transcipts of fibrogenesis in lipid-like carriers inhibits development liver fibrosis
DOI 10.1055/s-0032-1323964
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Jiménez Calvente, YO Kim, A Segal, V Kotelianski, T Novobrantseva, D Schuppan
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Antifibrotic therapies have to be specific (on target), efficient and free of major side effects. C12–200 lipid-like particles (LPs) consisting of epoxide terminated alkyl chains and secondary amine monomers permit efficient delivery of siRNA, minimizing interference with blood cells and plasma and being devoid of side effects. Intravenous C12–200 LPs allow efficient and safe delivery of small interfer…
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Zitierempfehlung
C Jiménez Calvente, YO Kim, A Segal, V Kotelianski, T Novobrantseva, D Schuppan (2012) In vivo delivery of siRNA to key transcipts of fibrogenesis in lipid-like carriers inhibits development liver fibrosis. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1323964
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