CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A frequent PNPLA3 variant predicts disease course in PSC patients with dominant bile duct strictures
DOI 10.1055/s-0032-1323980
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Autor:innenK Friedrich, C Rupp, JR Hov, KH Weiss, P Sauer, P Schemmer, W Stremmel, TH Karlsen, D Gotthardt
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: Primary sclerosing cholangitis (PSC) is caused by chronic inflammation of the bile ducts and can progress to end-stage liver disease. The rs738409 variant (I148M) of the PNPLA3 gene is associated with alcoholic and non-alcoholic liver disease and we evaluated its impact on the disease course of PSC. Methods: I148M polymorphism was screened in 121 PSC patients in a long-term prospective study coh…
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Zitierempfehlung
K Friedrich, C Rupp, JR Hov, KH Weiss, P Sauer, P Schemmer, W Stremmel, TH Karlsen, D Gotthardt (2012) A frequent PNPLA3 variant predicts disease course in PSC patients with dominant bile duct strictures. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1323980
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