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Differential regulation of depression associated interferon-inducible genes identified in HCV patients during IFN-alpha therapy in hippocampal and prefrontal cortex mouse neurons

C Hoyo-Becerra, A Huebener, M Trippler, L Poggenpohl, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · Ausgabe 08/2012

DOI 10.1055/s-0032-1323991

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Autor:innenC Hoyo-Becerra, A Huebener, M Trippler, L Poggenpohl, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben

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Aims: In previous studies, 16 genes strongly associated with the development of severe depressive side effects during the standard therapy with IFN-α and ribavirin were identified in the peripheral blood of HCV patients. In addition, an enhanced expression of such genes was found in psychiatric patients undergoing severe depression and in autopsy brain tissue from suicidal individuals. Aims: The present study elucid…

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C Hoyo-Becerra, A Huebener, M Trippler, L Poggenpohl, G Gerken, JF Schlaak (2012) Differential regulation of depression associated interferon-inducible genes identified in HCV patients during IFN-alpha therapy in hippocampal and prefrontal cortex mouse neurons. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1323991

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