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Innate immune defence defines susceptibility of gastrointestinal and non-gastrointestinal sarcomas to measles vaccine virus based virotherapy

S Berchtold, J Lampe, T Weiland, I Smirnow, S Schleicher, R Handgretinger, HG Kopp, J Reiser, F Stubenrauch, NP Malek, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · Ausgabe 08/2012

DOI 10.1055/s-0032-1324020

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Autor:innenS Berchtold, J Lampe, T Weiland, I Smirnow, S Schleicher, R Handgretinger, HG Kopp, J Reiser, F Stubenrauch, NP Malek, M Bitzer, UM Lauer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: The oncolytic potential of measles vaccine virus (MeV) has been demonstrated in several tumor models but it has also been shown that primary and secondary resistances exist or may arise. To improve the oncolytic potential of MeV and to overcome resistances, a suicide gene (SCD) was inserted encoding a fusion protein of the enzymes yeast cytosine deaminase and yeast uracil phosphoribosyltransferase (MeV…

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S Berchtold, J Lampe, T Weiland, I Smirnow, S Schleicher, R Handgretinger, HG Kopp, J Reiser, F Stubenrauch, NP Malek, M Bitzer, UM Lauer (2012) Innate immune defence defines susceptibility of gastrointestinal and non-gastrointestinal sarcomas to measles vaccine virus based virotherapy. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1324020

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