CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inhibition of Notch signaling attenuates epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells
DOI 10.1055/s-0032-1324051
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Autor:innenV Palagani, M El Khatib, U Kossatz, B Przemyslaw, M Müller, M Manns, T Krech, N Malek, R Plentz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high rate of metastasis and limited treatment options. The Notch pathway has recently emerged as a candidate drug target. Notch signalling is important in PDAC initiation and maintenance. A number of subpopulations within PDAC have been shown to have tumor initiating or cancer stem cells (CSC) properties. This provides a rationale…
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Zitierempfehlung
V Palagani, M El Khatib, U Kossatz, B Przemyslaw, M Müller, M Manns, T Krech, N Malek, R Plentz (2012) Inhibition of Notch signaling attenuates epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1324051
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