CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
IL-17A amplifies TNF-alpha-induced inflammation in intestinal epithelial cells via up-regulation of pro-inflammatory chemokines and cytokines including IL-17C and inflammatory bowel disease risk gene transcripts
DOI 10.1055/s-0032-1324107
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Friedrich, J Diegelmann, S Brand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: IL-17-secreting Th17 cells play a major role in the pathogenesis of inflammatory bowel diseases (IBD). However, clinical trials in IBD patients using anti-IL-17 antibodies lacked clinical efficacy. We therefore analyzed how IL-17 modulates the proinflammatory response elicited by TNF-alpha in intestinal epithelial cells (IEC). Methods: Target gene activation by TNF-alpha, IL-17A and by combined…
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Zitierempfehlung
M Friedrich, J Diegelmann, S Brand (2012) IL-17A amplifies TNF-alpha-induced inflammation in intestinal epithelial cells via up-regulation of pro-inflammatory chemokines and cytokines including IL-17C and inflammatory bowel disease risk gene transcripts. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1324107
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