CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
IL-27 activates MHC class II expression in intestinal epithelial cells via STAT1-dependent class II transactivator (CIITA) induction
DOI 10.1055/s-0032-1324108
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Diegelmann, M Friedrich, S Brand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: IL-27 is a Th17-cell inhibiting cytokine produced by antigen presenting cells. We recently demonstrated anti-inflammatory and antibacterial functions for IL-27 in intestinal epithelial cells (IEC) and identified CIITA as IL-27 target gene [1]. Both IL-27 and CIITA have been implicated in the susceptibility to inflammatory bowel diseases and certain autoimmune diseases. Here we aimed to analyze the role…
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Zitierempfehlung
J Diegelmann, M Friedrich, S Brand (2012) IL-27 activates MHC class II expression in intestinal epithelial cells via STAT1-dependent class II transactivator (CIITA) induction. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0032-1324108
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