Stammzellveränderung bei MDS

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Myelodysplastic syndromes (MDS) are clinically characterized by two important features: ineffective hematopoiesis leading to bone marrow failure and a propensity to transform to acute myeloid leukemia (AML). Although the pathophysiology is not entirely understood there is large body of evidence that the disease phenotype originates from the compartment of hematopoietic stem cells (HSC) in the bone marrow. In fact, t…

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