CareLit · DOI-Nachweis · Pneumologie
The Notch mediator RBP-J in CD4 T cells plays a crucial role in the induction of allergic asthma in mice
DOI 10.1055/s-0032-1329794
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Hendriks, A KleinJan, M De Bruijn, M Van Nimwegen, I Bergen, H Hoogsteden, D Amsen
ZeitschriftPneumologie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Although asthma is a complex disease, studies in patients and animal models have shown that enhanced activation of T helper-2 (Th2) cells and their cytokines explain many disease hallmarks. These include immunoglobulin E synthesis (IL-4), airway eosinophilia (IL-5), mast cell accumulation (IL-9), goblet cell hyperplasia (IL-4, IL-13) and bronchial hyperreactivity (IL-13). Central to the initiation of Th2 differentia…
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Zitierempfehlung
R Hendriks, A KleinJan, M De Bruijn, M Van Nimwegen, I Bergen, H Hoogsteden, D Amsen (2012) The Notch mediator RBP-J in CD4 T cells plays a crucial role in the induction of allergic asthma in mice. Pneumologie (11). https://doi.org/10.1055/s-0032-1329794
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