CareLit · DOI-Nachweis · Pneumologie
A potential role of the proteoglycan biglycan in a murine model of allergic airway inflammation
DOI 10.1055/s-0032-1329800
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Autor:innenA Zech, T Müller, M Idzko
ZeitschriftPneumologie
Ausgabe11/2012
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
The extracellular matrix component biglycan (Bgn) is a small leucine-rich proteoglycan (SLRP) is known to act as damage-associated pattern (DAMP)(Schaefer, Liliana, et al. (2008) J Biol Chem, 283, 21305). Following secretion by activated macrophages or proteolytic digestion the soluble biglycan is capable of binding to TLR2, TLR4 and P2×7 thereby triggering downstream signaling events leading to an increased product…
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Zitierempfehlung
A Zech, T Müller, M Idzko (2012) A potential role of the proteoglycan biglycan in a murine model of allergic airway inflammation. Pneumologie (11). https://doi.org/10.1055/s-0032-1329800
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